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Introduction to Population Pharmacokinetic / Pharmacodynamic Analysis with Nonlinear Mixed Effects Models
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This book provides a user-friendly, hands-on introduction to the Nonlinear Mixed Effects Modeling (NONMEM) system, the most powerful tool for pharmacokinetic / pharmacodynamic analysis. • Introduces requisite background to using Nonlinear Mixed Effects Modeling (NONMEM), covering data requirements, model building and evaluation, and quality control aspects • Provides examples of nonlinear modeling concepts and estimation basics with discussion on the model building process and applications of empirical Bayesian estimates in the drug development environment • Includes detailed chapters on data set structure, developing control streams for modeling and simulation, model applications, interpretation of NONMEM output and results, and quality control • Has datasets, programming code, and practice exercises with solutions, available on a supplementary website
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Product details
Hardcover: 320 pages
Publisher: Wiley; 1 edition (July 8, 2014)
Language: English
ISBN-10: 9780470582299
ISBN-13: 978-0470582299
ASIN: 0470582294
Product Dimensions:
6.1 x 0.9 x 9.3 inches
Shipping Weight: 1.2 pounds (View shipping rates and policies)
Average Customer Review:
5.0 out of 5 stars
2 customer reviews
Amazon Best Sellers Rank:
#917,165 in Books (See Top 100 in Books)
I love this book. The authors clearly and concisely explain all the essential concepts needed to perform population pharmacokinetic modeling and simulation. Together with PLT Tools' manual, this book can guide anyone new to NONMEM to build the first population PK model.
Excellent book, I'm a “really beginner†into this sort of analytical tool. I tried to read others sources but obviously were a complex starting point.
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